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KMID : 0357920090430040368
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Korean Journal of Pathology
2009 Volume.43 No. 4 p.368 ~ p.373
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Morphological Features of Metastatic Gastrointestinal Stromal Tumors after Gleevec Treatment - Two Cases Report -
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Choi Joon-Hyuk
Bae Young-Kyung
Song Sun-Kyo
Kim Hong-Jin
Shim Min-Chul
Lee Kyoung-Hee
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Abstract
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We report two patients with metastatic gastrointestinal stromal tumors (GISTs) with a focus on the morphological features related to Gleevec treatment. In case 1, a 50-year-old woman presented with a 1.8 cm metastatic GIST in the liver after resection of a gastric GIST. Majority of the metastatic tumor showed fibrosis and hyalinization after 8 weeks of Gleevec treatment. CD117-positive cells were present in approximately 1% of the overall tumor. In case 2, a 2 cm and 14 cm metastatic liver masses were found in a 54-year-old man who had a rectal GIST. After 4 weeks of Gleevec treatment, metastatic tumors showed a decrease in size on CT scan. The metastatic tumors showed a decrease in number of tumor cells. The hemorrhage, cystic changes, necrosis, and fibrosis made up approximately 90% of the tumor. The morphological features related to Gleevec treatment are important for correct diagnosis and evaluation of tumor response and prognosis.
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KEYWORD
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Gastrointestinal stromal tumor, Gleevec, Liver, Metastasis, Morphology
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